AMH in Midlife: What the Numbers Really Mean

AMH (Anti-Müllerian Hormone) is often used as a measure of ovarian reserve — the estimated number of eggs remaining in your ovaries. In midlife, AMH levels naturally decline as egg numbers decrease, but a low AMH alone doesn’t mean you’re in menopause or that your health is at risk.

Why This Matters in Midlife

When egg numbers drop significantly, estrogen production from the ovaries also falls. This lower estrogen level is what leads to the classic perimenopausal and menopausal symptoms — hot flashes, night sweats, vaginal dryness, and sleep changes.

But here’s the nuance:

• You can have a low AMH but still have enough estrogen to keep cycles going and symptoms minimal.

• You can also have perimenopausal symptoms even before your AMH is extremely low.

• AMH tells us about quantity of eggs, but not the quality, and it doesn’t directly measure estrogen.

Bottom Line

A low AMH in your 40s is expected — but understanding how that number relates to your estrogen levels can help clarify whether symptoms are due to perimenopause, menopause, or something else entirely.

At femcare.org, we interpret AMH alongside estrogen, FSH, and other hormone results to give you the full picture.

📅 Check back on Friday for Fertility Friday, when we’ll cover how AMH plays a role in fertility at every age.

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