The Truth About Bioidentical vs. Traditional Hormone Therapy
Hormone therapy can feel like a mystery — and “bioidentical” sounds so natural, but is it really better? Let’s break it down so you can feel confident and informed.
What Does “Bioidentical” Even Mean?
Bioidentical hormones have the same chemical structure as the hormones your body naturally makes. They’re made from plant sources (like yams or soy) and processed in a lab to match human hormones like estrogen or progesterone.
FDA-Approved vs. Compounded
There are two main ways bioidentical hormones are used:
FDA-Approved Bioidentical HRT: These are standard prescription pills, patches, creams, or gels that go through strict safety and quality checks. Examples include estradiol patches (like Vivelle-Dot) or progesterone capsules (Prometrium).
Compounded Bioidentical HRT: Customized formulas mixed by specialty pharmacies — for example, a custom cream with estrogen, progesterone, or testosterone. These are not FDA-approved and aren’t tested for safety or consistency in the same way.
Are Bioidenticals Safer?
Not always. Many women think “bioidentical” means risk-free, but the risks are the same:
Blood clots, stroke, and breast cancer risks are linked to how hormones are absorbed (pill vs. patch) and dose — not whether they’re “bioidentical” or traditional.
Compounded hormones may vary in strength and purity since they’re not regulated by the FDA.
What’s the Best Option?
There’s no one-size-fits-all. For most women, FDA-approved hormone therapy is the safest starting point — you know exactly what you’re getting. If you need something custom (like an unusual dose or delivery method), compounded may help, but it’s important to work with a trusted, experienced provider.
Key Takeaway
Bioidentical doesn’t always mean “better.” It means “biologically identical” — that’s all! Always choose hormone therapy that’s evidence-based, safe, and tailored to you.
💗 Thinking About HRT?
You don’t have to figure this out alone. Midlife hormone health is complex, but you deserve to feel your best and know your options. Book a free 10-minute informational consult with a femcare nurse practitioner. We’re here to listen, support, and help you explore your options — at your pace.
👉 Schedule now